Nutraceuticals have gained lot of attention in the present-day world as it seems to promote potential benefits in several chronic ailments including neurodegeneration, antioxidant and several other diseases. Solid Lipid Nanoparticles (SLN) is alternative drug delivery system to colloidal drug delivery system such as liposome, lipid emulsions. In this present study the SLN loaded with nutraceutical, piperine has been formulated and evaluated for determining the characteristics. Piperine was prepared as SLN by emulsion technique under the high shear homogenizer at the speed of 20,000rpm for 5min. The prepared SLN were subjected to various evaluations such as particle size, encapsulation efficiency, drug content and invitro release studies. The results showed that the SLN loaded with piperine average size were found to be 130nm and the zeta potential results shown that there was a good size distribution of the particles. The encapsulation efficiency of piperine was 99.17%. The in vitro release was predominantly by diffusion phenomenon explained by korsmeyerpeppas followed Higuchiâ??s model. The stability studies are indicative that the prepared SLN were stable. The SLNs of nutraceutical drug piperine was undergone various characterization studies after being formulated with various types of lipids, surfactants and cosurfactants. From the invitro kinetic model the drug release profile of the formulation has been concluded that the formulation follows the higuchi model of diffusion. The results are evident that the average size of SLN may play a significant role in bioavailability enhancement. To conclude, SLN loaded piperine can be useful for studying its in vivo characteristics.
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